Sarecycline hydrochloride

Research use only, not for human use.

Sarecycline hydrochloride (Sarecycline HCl) is an orally active narrow-spectrum tetracycline antibiotic with antimicrobial and anti-inflammatory activity, inhibits Acinetobacter and Candida tropicalis, and can be used to treat inflammatory acne.

Sarecycline hydrochloride is an orally active narrow-spectrum tetracycline derivative antibiotic. Sarecycline hydrochloridehas anti-inflammatory activity. Sarecycline hydrochloride inhibits the activity of Gram-positive bacteria and several types of keratobacterium acnes. Sarecycline hydrochloride interferes with tRNA accommodation and tethers mRNA to the 70S ribosome. Sarecycline hydrochloride can be used to study moderate to severe acne.

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Animal Model:Female SD-1 mice (A murine neutropenic thigh wound infection model)Dosage:0.33, 1, 3, or 9?mg/kg Administration:Intravenously Result:Achieved a 2-log10 reduction in the bacterial burden in the thigh at a dose comparable to that of doxycycline, with ED50s of 8.23 and 8.32?mg/kg, respectively.Animal Model:Carrageenan-induced footpad edema male Sprague Dawley rats model Dosage:1 mg/kg, 5 mg/kg ,10 mg/kg, 25 mg/kg, 50 mg/kg, 75 mg/kg,100 mg/kg, 150 mg/kg Administration:Intraperitoneal injection (i.p.); Single dose. Before a subplantar injection of sterile 1 mg/0.1 mL carrageenan solution in the right hind paw. Result: Reduced inflammation to 55.7% and 53.1%, respectively, at doses of 75 mg/kg and 100 mg/kg compared to baseline.

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GPCR/G Protein

Antibacterial

Antibacterial

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1035979-44-2

523.96

C24H30ClN3O8

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (190.85 mM; Ultrasonic )

O[C@]12[C@]([C@H](N(C)C)C(O)=C(C(N)=O)C1=O)(C[C@]3(C(=C2O)C(=O)C=4C(C3)=C(CN(OC)C)C=CC4O)[H])[H].Cl

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(-20℃)

With Ice Pack

≥ 2 years